Table 5 Five-year OS and RFS for stage 1 and stage 2 patients without MYCNA

From: Treatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma Group

 

Stage 1

Stage 2

Characteristics

Cases

No. of deaths

OS

P -value

No. of events

RFS

P -value

Cases

No. of deaths

OS

P -value

No. of events

RFS

P -value

 

288

3

98.9

 

16

94.3

 

123

9

93.2

 

22

82.8

 

Gender

      

<0.05

   

0.79

  

0.16

 Male

167

   

13

92

 

61

4

93.2

 

8

88.5

 

 Female

121

   

3

97.5

 

62

5

93.4

 

14

77.4

 

Age (years)

      

0.91

   

0.07

  

0.90

 0–17

185

   

10

94.5

 

76

3

96.0

 

14

81.5

 

18

103

   

6

94.1

 

47

6

88.7

 

8

85.0

 

Primary site

      

0.79

   

0.45

  

0.076

 Neck

14

   

1

92.9

 

7

1

100

 

2

71.4

 

 Thorax

65

   

3

95.4

 

43

2

95.3

 

4

90.7

 

 Abdomen

197

   

12

93.7

 

61

6

89.6

 

11

81.8

 

 Pelvis

12

   

0

100

 

12

0

100

 

5

66.7

 

LN infiltration

          

0.50

  

0.79

 Absent

0

      

53

3

94.3

 

9

83.0

 

 Present

0

      

70

6

92.4

 

13

82.7

 

Serum LDH

      

0.061

   

<0.0001

  

0.050

 Normal

161

   

7

95.6

 

95

5

95.7

 

15

85.2

 

 Increased

12

   

2

83.3

 

8

4

50

 

3

62.5

 

 Missing

115

      

20

      

Urine VMA

      

0.44

   

0.20

  

0.87

 Normal

118

   

5

95.8

 

32

3

90.4

 

6

84.4

 

 Increased

57

   

4

92.8

 

40

1

97.5

 

7

82.5

 

 Missing

113

      

51

      

Urine HVA

      

0.28

   

0.31

  

0.39

 Normal

108

   

4

96.3

 

36

3

91.4

 

8

80.6

 

 Increased

52

   

4

92.1

 

35

1

97.1

 

5

85.7

 

 Missing

128

      

52

      

Histopathologic category

      

0.78

   

<0.0004

  

<0.0035

 Favourable

191

   

10

94.7

 

83

3

96.4

 

12

85.5

 

 Unfavourable

25

   

1

96

 

21

6

75.9

 

9

61.2

 

 Missing

72

      

19

      

DNA index

      

0.40

   

0.31

  

0.40

 Aneuploid

90

   

7

92.2

 

47

3

93.6

 

8

83

 

 Di-tetraploid

50

   

4

91.5

 

29

4

85.9

 

7

79.3

 

 Missing

148

      

47

      
  1. HVA=homovanillic acid; LDH=lactate dehydrogenase; LN=lymph node; OS=overall survival; RFS=relapse-free survival; VMA=vanillylmandelic acid.