Figure 5
Lysophosphatidic acid (LPA)-mediated cell invasion occurs by cytoskeletal rearrangement events. The effect of cytochalasin D (CyD) on (A); the in vitro migration of AGS gastric cancer cells treated with LPA, NET1 siRNA or C3 exoenzyme, and (B) the in vitro invasion of these cells. Cells were treated with siRNA for 48 h before treatment with or without LPA, C3 or CyD, 24 h after which the effects on invasion and migration were assessed (*,‡P<0.05). Error bars represent standard deviation of triplicate experiments.
