Figure 2 | British Journal of Cancer

Figure 2

From: Regulatory potential for concerted modulation of Nrf2- and Nfkb1-mediated gene expression in inflammation and carcinogenesis

Figure 2

Multiple species alignment. Non-coding sequences of Nfe2l2 and Nfkb1 genes in five mammalian species – human, chimpanzee, dog, mouse and rat – were retrieved using the Non-Coding Sequence Retrieval System (NCSRS) for comparative genomic analysis of gene regulatory elements. Multiple sequence alignment was performed by submitting the non-coding sequences to MLAGAN and visualised by projecting them to pairwise alignments with respect to one reference sequence (human) as baseline. Pink regions, conserved non-coding sequences (CNS); dark blue regions, exons. The numbers indicate CNS that were identified across species. (A) Multiple species alignment for Nfe2l2; (B) multiple species alignment for Nfkb1; (C) phylogenetic tree for Nfe2l2 and Nfkb1; (D) a conserved TFBS between NFE2L2 and NFKB1 among top matching human sequences.

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