Table 2 Human and murine matrix families conserved between Nrf2 and Nfkb1
Matrix family (Human NRF2 vs NFKB1) | Matrix family (Murine Nrf2 vs Nfkb1) | Matrix family conserved after multiple species alignment (NRF2 vs NFKB1) | Family information |
---|---|---|---|
– | V$AHRR | – | AHR-arnt heterodimers and AHR-related factors |
– | – | V$AIRE | Autoimmune regulatory element-binding factor |
– | – | V$AP1R | MAF- and AP1-related factors |
– | V$AP2F | – | Activator protein 2 |
V$AP4R | V$AP4R | – | Activator protein 4 and related proteins |
– | – | V$ATBF | AT-binding transcription factor |
– | V$BCL6 | V$BCL6 | POZ domain zinc finger expressed in B-cells |
– | – | V$BRAC | Brachyury gene, mesoderm developmental factor |
– | – | V$BRNF | Brn POU domain factors |
– | – | V$CAAT | CCAAT-binding factors |
– | – | V$CART | Cart-1 (cartilage homoeoprotein 1) |
– | – | V$CDXF | Vertebrate caudal related homoeodomain protein |
V$CEBP | – | – | Ccaat/enhancer-binding protein |
V$CHRF | – | V$CHRF | Cell cycle regulators: cell cycle homology element |
– | – | V$CIZF | CAS-interating zinc finger protein |
– | – | V$CLOX | CLOX and CLOX homology (CDP) factors |
– | – | V$COMP | Factors that cooperate with myogenic proteins |
V$CREB | – | V$CREB | Camp-responsive element-binding proteins |
– | V$CTCF | – | CTCF and BORIS gene family, transcriptional regulators with 11 highly conserved zinc finger domains |
V$E2FF | V$E2FF | – | E2F-myc activator/cell cycle regulator |
– | V$E4FF | – | Ubiquitous GLI-krueppel-like zinc finger involved in cell cycle regulation |
V$EBOX | V$EBOX | – | E-box-binding factors |
– | V$EGRF | – | EGR/nerve growth factor-induced protein C and related factors |
V$EKLF | V$EKLF | V$EKLF | Basic and erythroid krueppel-like factors |
– | V$EREF | – | Estrogen response elements |
V$ETSF | V$ETSF | – | Human and murine ETS1 factors |
– | – | V$EVI1 | EVI1 myeloid-transforming protein |
V$FKHD | – | V$FKHD | Fork head domain factors |
– | V$FXRE | – | Farnesoid X-activated receptor response elements |
V$GATA | V$GATA | V$GATA | GATA-binding factors |
V$GFI1 | – | V$GFI1 | Growth factor independence transcriptional repressor |
– | – | V$GREF | Glucocorticoid responsive and related elements |
– | – | V$GRHL | Grainyhead-like transcription factors |
V$HAND | – | – | bHLH transcription factor dimer of HAND2 and E12 |
– | V$HEAT | V$HEAT | Heat-shock factors |
– | V$HESF | – | Vertebrate homologues of enhancer of split complex |
– | – | V$HNF1 | Hepatic nuclear factor 1 |
– | – | V$HNF6 | Onecut homoeodomain factor HNF6 |
– | – | V$HOMF | Homoeodomain transcription factors |
– | – | V$HOXC | HOX–PBX complexes |
V$HOXF | V$HOXF | V$HOXF | Factors with moderate activity to homoeodomain consensus sequence |
– | V$IKRS | – | Ikaros zinc finger family |
– | – | V$IRFF | Interferon regulatory factors |
V$LEFF | – | V$LEFF | LEF1/TCF, involved in the Wnt signal transduction pathway |
– | – | V$LHXF | Lim homoeodomain factors |
V$MAZF | V$MAZF | – | Myc-associated zinc fingers |
– | – | V$MEF2 | MEF2, myocyte-specific enhancer-binding factor |
V$MYBL | – | – | Cellular and viral myb-like transcriptional regulators |
V$MYOD | V$MYOD | – | Myoblast-determining factors |
– | – | V$MYT1 | MYT1 C2HC zinc finger protein |
– | V$MZF1 | – | Myeloid zinc finger 1 factors |
V$NEUR | – | V$NEUR | NeuroD, β2, HLH domain |
– | – | V$NF1F | Nuclear factor 1 |
– | – | V$NFAT | Nuclear factor of activated T cells |
– | V$NFKB | – | Nuclear factor κ B/c-rel |
– | – | V$NKX6 | NK6 homoeobox transcription factors |
– | – | V$NKXH | NKX homoeodomain factors |
V$NR2F | V$NR2F | V$NR2F | Nuclear receptor subfamily 2 factors |
– | V$NRF1 | – | Nuclear respiratory factor 1 |
– | – | V$OCT1 | Octamer-binding protein |
– | – | V$OCTP | OCT1-binding factor (POU-specific domain) |
V$P53F | V$P53F | – | p53 tumour suppressor |
– | – | V$PARF | PAR/bZIP family |
V$PAX5 | – | – | PAX-5 B cell-specific activator protein |
– | V$PAX6 | V$PAX6 | PAX-4/PAX-6 paired domain-binding sites |
– | – | V$PBXC | PBX1–MEIS1 complexes |
– | – | V$PDX1 | Pancreatic and intestinal homoeodomain transcription factor |
– | – | V$PERO | Peroxisome proliferator-activated receptor |
– | – | V$PIT1 | GHF-1 pituitary-specific pou domain transcription factor |
– | V$PLAG | – | Pleomorphic adenoma gene |
V$PLZF | – | V$PLZF | C2H2 zinc finger protein PLZF |
– | – | V$PRDF | Positive regulatory domain I-binding factor |
– | – | V$PTF1 | Pancreas transcription factor 1, heterotrimeric transcription factor |
– | – | V$RBIT | Regulator of B-cell IgH transcription |
– | – | V$RUSH | SWI/SNF-related nucleophosphoproteins with a RING finger DNA-binding motif |
V$RXRF | V$RXRF | V$RXRF | RXR heterodimer-binding sites |
– | – | V$SATB | Special AT-rich sequence-binding protein |
V$SF1F | – | V$SF1F | Vertebrate steroidogenic factor |
– | V$SMAD | – | Vertebrate SMAD family of transcription factors |
– | – | V$SNAP | snRNA-activating protein complex |
V$SORY | V$SORY | V$SORY | SOX/SRY-sex/testis-determining and related HMG box factors |
V$SP1F | V$SP1F | V$SP1F | GC-Box factors SP1/GC |
– | V$SRFF | V$SRFF | Serum response element-binding factor |
V$STAT | – | V$STAT | Signal transducer and activator of transcription |
– | – | V$TALE | TALE homoeodomain class-recognising TG motifs |
– | V$TBPF | V$TBPF | Tata-binding protein factor |
– | V$WHNF | – | Winged helix-binding sites |
V$XBBF | – | – | X-box-binding factors |
V$ZBPF | V$ZBPF | – | Zinc-binding protein factors |
V$ZF35 | – | – | Zinc finger protein ZNF35 |
V$ZFHX | – | V$ZFHX | Two-handed zinc finger homoeodomain transcription factors |