Table 3 Number of patients with dose-limiting toxicity (DLT) by dose level
Dose level | 1 ( n =6) | 2 ( n =6) | 3 ( n =6) | 4 ( n =7) | 5 ( n =5) | Combined ( n =30) |
|---|---|---|---|---|---|---|
Number of patients with DLT | 2 | 1 | 2 | 1 | 3 | 9 |
Number of DLTs | 3 | 2 | 3 | 1 | 3 | 12 |
Type of DLT | ||||||
Anorexia | 1 | 1 | 1 | 1 | — | 4 |
Asthenia | 1 | — | 1 | — | 2 | 4 |
Epithelitis | 1 | — | — | — | — | 1 |
Febrile neutropenia | — | — | 1 | — | — | 1 |
Infection | — | 1 | — | — | — | 1 |
Diarrhoea | — | — | — | — | 1 | 1 |
