Table 1 Analysis of function of differentially expressed genes

From: A genome-wide expression analysis identifies a network of EpCAM-induced cell cycle regulators

 

Number of differentially expressed genes (induced/repressed)

  

(A) Functional category

A2C12

A549

Caco-2

A2C12/A549 a

  

Cell cycleb

232 (126/106)

153 (73/80)

33 (25/8)

29 (20/9)

  

Cellular growth and proliferationc

415 (204/211)

306 (139/167)

46 (33/13)

48 (29/19)

  

Cell deathd

395 (202/193)

265 (128/137)

62 (48/14)

49 (33/16)

  

Cancere

462 (242/220)

344 (155/189)

77 (54/23)

54 (31/23)

  
 

Number of differentially expressed genes (induced/repressed)

(B) Cell cycle phase

A2C12

A549

Caco-2

A2C12/A549/Caco-2 a

A2C12/A549 a

A549/Caco-2 a

G0/G1 phases and G1/S transition

58 (25/33)

38 (20/18)

8 (5/3)

2 (2/0)

9 (6/3)

3 (2/1)

S phase

36 (21/15)

28 (16/12)

1 (0/1)

1 (1/0)

4 (3/0)

1 (0/1)

G2/M phases

38 (27/11)

18 (12/6)

5 (4/1)

3 (3/0)

4 (4/0)

0

  1. (A) Most significantly over-represented functional categories in the group of significantly regulated genes are shown. (B) Analysis of cell cycle-related differentially expressed genes.
  2. aCommonly modulated in the cell lines mentioned.
  3. bIncludes the functions and stages of the cell cycle including cell division. Functions associated with mitosis and meiosis are included in this category. Some examples of functions in this category are assembly of telomeres, cell cycle progression, and G0 phase of cells.
  4. cIncludes functions associated with the growth and proliferation of cells. Some examples of these functions include colony formation, proliferation, and outgrowth of cells.
  5. dIncludes functions associated with cellular death and survival. Some examples of functions included in this category are cytolysis, necrosis, survival, and recovery of cells.
  6. eIncludes functions associated with cancer. This includes any process associated with a tumour, cancer cell, or cancerous tissue, as well as any object associated with a cancer process such as transformation and metastasis. This category also includes all cancerous diseases.