Table 2 Correlation between TIL density and clinicopathologic characteristics in the 220 gastric cancers

From: Prognostic implications of type and density of tumour-infiltrating lymphocytes in gastric cancer

 

CD3 + TIL

CD8 + TIL

CD45RO + TIL

Characteristics

Low

High

P -value*

Low

High

P -value*

Low

High

P -value*

Age (years)

  

0.026

  

0.250

  

0.167

 <66

108

69

 

129

48

 

121

56

 

 ⩾66

34

9

 

35

8

 

34

9

 

Gender

  

0.023

  

0.109

  

0.315

 Male

108

48

 

121

35

 

113

43

 

 Female

34

30

 

43

21

 

42

22

 

WHO classification

  

0.148

  

0.008

  

0.118

 WD

9

3

 

11

1

 

9

3

 

 MD

50

23

 

58

15

 

53

20

 

 PD

58

44

 

65

37

 

65

37

 

 Mucinous

9

1

 

9

1

 

10

0

 

 SRC

16

7

 

21

2

 

18

5

 

Lymphatic invasion

  

0.143

  

0.590

  

0.446

 Absent

88

56

 

109

35

 

99

45

 

 Present

54

22

 

55

21

 

56

20

 

Tumour stage

  

0.095

  

0.924

  

0.366

 T1/2

98

62

 

119

41

 

110

50

 

 T3/4

44

16

 

45

15

 

45

15

 

LN metastasis

  

<0.001

  

0.012

  

<0.001

 Absent

24

31

 

34

21

 

28

27

 

 Present

118

47

 

130

35

 

127

38

 

TNM stage

  

0.001

  

0.250

  

0.018

 I

32

35

 

44

23

 

38

29

 

 II

32

21

 

41

12

 

38

15

 

 III

44

11

 

44

11

 

45

10

 

 IV

34

11

 

35

10

 

34

11

 
  1. LN=lymph node; MD=moderately differentiated tubular adenocarcinoma; Mucinous=mucinous adenocarcinoma; PD=poorly differentiated tubular adenocarcinoma; SRC=signet-ring cell carcinoma; WD=well differentiated tubular adenocarcinoma.
  2. The results were according to the density groups of TIL with mean value cutoffs.
  3. *χ2 test was used as a statistical method.
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