Table 3 Toxicities grade 2

From: Preoperative bevacizumab combined with letrozole and chemotherapy in locally advanced ER- and/or PgR-positive breast cancer: clinical and biological activity

 

Grade 2

Grade 3

Grade 4

 

N

%

N

%

N

%

Leukopaenia

5

14

5

14

0

(−)

Neutropaenia

4

14

12

14

4

11

Nausea

7

19

0

(−)

0

(−)

Vomiting

3

5

0

(−)

0

(−)

Diarrhoea

2

(−)

0

(−)

0

(−)

Stipsis

8

22

1

3

2

8

Mucositis

7

19

2

5

0

(−)

Biochemicala

5

14

3

8

0

(−)

Neurological

0

(−)

1

3

0

(−)

Myalgia

1

3

0

(−)

0

(−)

Asthaenia

5

14

1

3

2

8

Epigastralgia

4

11

0

(−)

0

(−)

HFS

4

11

1

3

1

4

DVT

0

(−)

4

11

0

(−)

Hypertension

7

19

2

5

0

(−)

Proteinuria

1

3

0

(−)

0

(−)

Infection/fever

2/2

5/5

0/2

0/5

0

(−)

  1. DVT=deep venous thrombosis; HFS=hand–foot syndrome.
  2. aIncluded alteration of liver function (AST, ALT and bilirubin).