Table 4 Multivariate^a relative risks (RR) and 95% confidence intervals (CI) of epithelial ovarian cancer according to childhood body fatness and BMI at the age of 18 years, by menopausal status

	Premenopausal (NHS and NHSII)			Postmenopausal (NHS and NHSII)
	Cases	Person-years	Multivariate ^a RR (95% CI)	Cases	Person-years	Multivariate ^a RR (95% CI)
Average body fatness at the ages of 5 and 10 years ^b
1	25	239 481	1.0 (REF)	123	250 962	1.0 (REF)
1.5–2	44	422 079	1.16 (0.71–1.90)	96	232 530	0.89 (0.68–1.17)
2.5–3	32	345 738	0.96 (0.57–1.64)	59	167 233	0.79 (0.58–1.08)
3.5–4.5	31	281 222	1.12 (0.65–1.90)	38	142 234	0.60 (0.42–0.87)
⩾5	13	85 055	1.38 (0.70–2.71)	24	60 158	0.85 (0.54–1.31)
P for trend^c			0.92			0.09
			P for interaction=0.37
BMI at the age of 18 years, kg m ⁻²
<20	64	657 807	1.0 (REF)	172	446 874	1.0 (REF)
20–20.9	38	313 846	1.22 (0.81–1.83)	81	236 512	0.90 (0.69–1.18)
21–22.9	53	401 364	1.22 (0.84–1.77)	125	322 686	1.04 (0.83–1.32)
23–24.9	26	183 682	1.40 (0.88–2.21)	61	153 997	1.04 (0.78–1.40)
⩾25	26	170 607	1.41 (0.89–2.24)	43	123 277	0.91 (0.65–1.27)
P for trend^d			0.10			0.85
			P for interaction=0.11

^aMultivariate analyses adjusted for age (continuous), parity (continuous), duration of oral contraceptive use (continuous), tubal ligation history (yes/no), and height (<1.6, 1.6 to <1.65, 1.65 to <1.7, 1.7 to <1.75, and ⩾1.75 m).
^bAverage childhood body fatness calculated by taking the average of each participant's body fatness at the ages 5 and 10 years.
^cP value from multivariate model with body fatness modelled as continuous variable.
^dP value from multivariate model with BMI at the age of 18 years modelled as medians of categories.

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