Table 5 Multivariatea relative risks (RR) and 95% confidence intervals (CI) of epithelial ovarian cancer according to height and birthweight, by study population

From: Body size in early life and risk of epithelial ovarian cancer: results from the Nurses' Health Studies

 

Nurses' Health Study (NHS)

Nurses' Health Study II (NHSII)

NHS and NHSII combined

 

Cases

Person- years

Multivariate a RR (95% CI)

Cases

Person-years

Multivariate a RR (95% CI)

Cases

Person-years

Multivariate a RR (95% CI)

Height, m

 <1.6

148

572 360

1.0 (REF)

18

314 588

1.0 (REF)

166

886 961

1.0 (REF)

 1.6 to <1.65

217

734 892

1.16 (0.94–1.43)

36

448 775

1.41 (0.80–2.49)

253

1 183 667

1.19 (0.98–1.45)

 1.65 to <1.7

198

710 542

1.11 (0.89–1.37)

35

452 681

1.39 (0.78–2.47)

233

1 163 223

1.14 (0.93–1.39)

 1.7 to <1.75

135

394 339

1.39 (1.10–1.75)

32

308 771

1.96 (1.10–3.50)

167

703 111

1.46 (1.17–1.81)

 ⩾1.75

37

116 768

1.27 (0.88–1.82)

16

129 593

2.35 (1.19–4.63)

53

246 361

1.43 (1.05–1.96)

 P for trendb

  

0.01

  

0.01

  

0.001

   

P for heterogeneityc=0.22

    

Birthweight, lbs

 <5.5

13

34 925

0.99 (0.55–1.78)

2

36 519

0.68 (0.16–2.84)

15

71 444

0.93 (0.54–1.60)

 5.5–6.9

69

165 868

1.08 (0.79–1.48)

29

303 063

1.19 (0.74–1.92)

98

468 931

1.11 (0.85–1.44)

 7.0–8.4

101

248 159

1.0 (REF)

45

527 664

1.0 (REF)

146

775 823

1.0 (REF)

 ⩾8.5

43

72 412

1.32 (0.92–1.90)

12

149 557

0.83 (0.44–1.58)

55

221 969

1.17 (0.85–1.60)

 P for trendd

  

0.58

  

0.45

  

0.92

   

P for heterogeneityc=0.35

    
  1. aMultivariate analyses for height adjusted for age (continuous), parity (continuous), duration of oral contraceptive use (continuous), tubal ligation history (yes/no), and body mass index at the age of 18 years (<20, 20–20.9, 21–22.9, 23–24.9, and ⩾25 kg m−2). Multivariate analyses for birthweight adjusted for same factors except height (<1.6, 1.6 to <1.65, 1.65 to <1.7, 1.7 to <1.75, and ⩾1.75 m) instead of body mass index at the age of 18 years.
  2. bP value from multivariate model with height modelled as medians of categories.
  3. cP for heterogeneity by cohort assessed using the DerSimonian and Laird random effects model.
  4. dP value from multivariate model with birthweight categories modelled as ordinal.
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