Table 2 Clinical parameters selected with stepwise backward selection in multivariate Cox-regression analyses including signature 2

From: Robust prognostic value of a knowledge-based proliferation signature across large patient microarray studies spanning different cancer types

 

Hazard ratio (95% CI)

P -value

Miller

 Tumor size

3.3 (1.7–6.6)

0.0006

 LNSa

2.8 (1.6–5.0)

0.0003

 Proliferationb

3.4 (1.4–8.2)

0.0052

Wang

 Proliferationb

2.6 (1.5–4.4)

0.0004

Van de Vijver

 Age

0.95 (0.91–0.99)

0.0096

 Tumour sizec

1.5 (0.93–2.5)

0.0962

 Elston grade

2.2 (1.4–3.4)

0.0003

 Proliferationb

21 (1.8–234)

0.0148

Zhao

 Performance status

1.3 (1.1–1.6)

0.0069

 Grade

1.5 (1.0–2.1)

0.0260

 Stage

3.3 (2.5–4.4)

< 0.0001

Beer

 Age

1.0 (1.0–1.1)

0.0338

 Stage

2.3 (1.5–3.5)

0.0002

 Proliferationb

1.8 (0.9–3.5)

0.0884

  1. aLNS=lymph-node status.
  2. bProliferation: proliferation signature 2.
  3. cCategories: ⩽2 or >2 cm.
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