Figure 1 | British Journal of Cancer

Figure 1

From: LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

Figure 1

(A) AutoDock4 molecular surface visualisation of the STAT3 SH2 domain (residues 582–702) secondary structure ribbon, with selected binding pocket residues and predicted correct docking conformation of ligand LLL-3 (chemical structure insert), rendered by ball-and-stick models, in the target PTR-binding pocket of STAT3. The small molecule LLL-3, an analogue of STA-21, forms two hydrogen bonds with specific residues ARG609 and ILE634. (B) The inhibitory effect of STAT3 DNA binding activity in U373 and MDA-MB-231 cells and STAT3 transcriptional activity in MDA-MB-231 cells by LLL-3. Statistical significance (P<0.05) relative to the untreated (in MDA-MB-231 cells) or DMSO (in U373 cells) is designated by an asterisk.

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