Figure 5

MRI image evaluation of U87 orthotopic glioblastoma model showed large tumours in the right frontal cortex of untreated control animals: midline shift was particularly evident (top row); LLL-3-treated animals showed tumours that were significantly smaller with decreased hyperintensity and no evidence of midline shift (bottom row). Volumetric analysis of the average tumour volume was estimated to be 17.2 mm3 for the untreated control mice and 17.0 mm3 for the LLL-3-treated mice.