Table 1 The expression of P-STAT3, T-STAT3, P-JAK2 and T-JAK2 in normal ovaries, benign, borderline and histological grades of ovarian tumours

From: Cross talk of signals between EGFR and IL-6R through JAK2/STAT3 mediate epithelial–mesenchymal transition in ovarian carcinomas

Antigen analysed

Normal ovaries

Benign tumours

Borderline tumours

Grade 1 tumours

Grade 2 tumours

Grade 3 tumours

Statistical analysis

P-STAT3

0 (1)

0 (2)

1 (1)

0 (3)

0 (2)

1 (3)

χ2=32.74

 

1 (4)

1 (5)

2 (3)

1 (4)

1 (5)

2 (4)

df=20, P=0.03

 

2 (1)

2 (1)

3 (6)

2 (1)

2 (3)

3 (3)

 
 

3 (2)

4 (2)

 

4 (1)

 

4 (1)

 
 

4 (1)

      

STAT3

0 (1)

1 (1)

1 (1)

4 (8)

3 (2)

2 (1)

χ2=28.69,

 

2 (2)

2 (3)

2 (2)

5 (2)

4 (4)

3 (4)

df=25, P=0.276

 

3 (3)

3 (2)

3 (3)

 

5 (4)

4 (4)

 
 

4 (3)

4 (2)

4 (3)

  

5 (2)

 
  

5 (1)

5 (2)

    

P-JAK2

0 (4)

0 (6)

0 (2)

2 (1)

3 (4)

NA

    

3 (1)

   

T-JAK2

0 (3)

1 (1)

2 (2)

2 (1)

4 (2)

4 (1)

χ2=46.73,

 

2 (1)

2 (1)

3 (3)

3 (2)

5 (8)

5 (8)

df=25, P=0.005

 

3 (2)

3 (3)

4 (4)

4 (4)

   
 

5 (3)

4 (3)

5 (1)

5 (3)

   
  

5 (2)

     
  1. The extent of epithelial P-STAT3, T-STAT3, P-JAK2 and T-JAK2 expression was scored in a blind manner in normal ovaries and serous, endometrioid, mucinous, clear cell and mixed ovarian carcinomas of different pathological grades. Scoring was performed as 0 (10%), 1 (11–25%), 2 (26–50%), 3 (51–75%), 4 (76–90%) and 5 (91–100%) of immunoreactivity. Values in the parenthesis indicate number of patients evaluated for each antigen in each category. The epithelial distribution of antigens among normal and different tumour groups was statistically analysed using χ2 calculation.