Table 1 Patient characteristics

From: A phase I–II study of the histone deacetylase inhibitor valproic acid plus chemoimmunotherapy in patients with advanced melanoma

Characteristic

N

Sex

 Male

17

 Female

15

Age, years

 Median

51

 Range

23–72

ECOG performance status

 0

26

 1

5

 2

1

Number of involved sites

 0

1

 1 (sc/ln)

6 (4/2)

 2

9

 >2

16

Tumor site

 M0

1

 Skin, sc, ln

11

 Lung

2

 Other visceral/(CNS)

18/(2)

Previous treatments

 Surgery

31

Adjuvant treatment

CT (DTIC)

1

IT (IF-α)

12

None

19

Treatment for metastatic disease

CT (DTIC/CVD)

4 (4/1)

IT (IF-α)

5

CT+IT

8

DTIC o CVD+IF-α (±IL-2)

7

DTIC o CVD+IL-2

1

 Hyperthermic isolated limb perfusion

1

 None

14

N. lines for metastatic disease

0/1/2/>2

14/8/6/4

Median (range)

1 (0–5)

  1. Abbreviations: sc=subcutaneous; ln=lymph nodes; CNS=central nervous system; ECOG=Eastern Cooperative Oncology Group; CT=chemotherapy; IT=immunotherapy; IF-α=interferon-α; DTIC=dacarbazine; CVD=cisplatin vinblastine dacarbazine.