Table 1 Patient characteristics

From: Irinotecan plus carboplatin for patients with carcinoma of unknown primary site

Characteristics

No. of patients

No. of patients enrolled

45

Age (years)

 Median

59

 Range

36–78

Sex

 Male

23

 Female

22

ECOG performance status

 0

19

 1

22

 2

4

Histologic type

 Adenocarcinoma (well and moderately differentiated)

21

 Poorly differentiated adenocarcinoma

9

 Squamous cell carcinoma

7

 Poorly differentiated carcinoma

5

 Clear cell carcinoma

1

 Small cell carcinoma

1

 Undifferentiated carcinoma

1

No. of disease sites

 1

13

 2

10

3

22

Site of disease

 Lymph node

40

 Lung

6

 Bone

4

 Liver

8

 Adrenal

2

 Malignant effusion

4

 Soft tissue

3

 Other

6

Prognostic index

 Culine et al (2002a) a

 

Good risk

29

Poor risk

16

 van der Gaast et al (1996) b

Good risk

19

Intermediate risk

19

Poor risk

7

  1. ECOG=Eastern Cooperative Oncology Group.
  2. aGood-risk patients had a performance status of 0 or 1 and normal serum lactate dehydrogenase (LDH) levels; poor-risk patients had a performance status of 2 or elevated serum LDH levels.
  3. bGood-risk patients had a performance status of 0 and serum alkaline phosphatase (ALP) levels of <1.25 × normal range (N); intermediate-risk patients had a performance status of 1 or serum ALP levels of 1.25 × N; poor-risk patients had a performance status of 1 and serum ALP levels of 1.25 × N.