Table 3 Toxicity profiles (frequency>10%)
From: Irinotecan plus carboplatin for patients with carcinoma of unknown primary site
Profile | Frequency (%) | No. of grade 3 (%) | No. of grade 4 (%) |
|---|---|---|---|
Haematologic toxicity | |||
Leukopaenia | 75.6 | 6 (13.3) | 4 (8) |
Neutropaenia | 80 | 6 (13.3) | 9 (20) |
Anaemia | 93.3 | 8 (17.8) | 3 (6.7) |
Thrombocytopaenia | 68.9 | 7 (15.6) | 2 (4.4) |
Non-haematologic toxicity | |||
Fatigue | 60 | 0 (0) | 0 (0) |
Appetite loss | 46.7 | 0 (0) | 0 (0) |
Nausea | 82.2 | 1 (2.2) | 0 (0) |
Vomiting | 26.7 | 1 (2.2) | 0 (0) |
Diarrhoea | 57.8 | 4 (8) | 0 (0) |
Constipation | 42.2 | 0 (0) | 0 (0) |
Skin rash | 20 | 0 (0) | 0 (0) |
Febrile neutropaenia | 13.3 | 5 (11.1) | 1 (2.2) |
