Table 1 Comparison of clinicopathological findings between FISH negative and positive gastric carcinomas
ERBB2 amplification | |||
|---|---|---|---|
Negative ( n =218) | Positive ( n =38) | P value | |
Age (years) | 66 (±10.8) | 63 (±13.6) | NS |
NS | |||
Sex | |||
Male | 127 (58.3%) | 18 (47.4%) | |
Female | 91 (41.7%) | 20 (52.6%) | |
Histopathological classification(s) | |||
Lauren | 0.007 | ||
Intestinal | 121 (55.5%) | 31 (81.6%) | |
Diffuse | 63 (28.9%) | 3 (7.9%) | |
Non classified | 34 (15.6%) | 4 (10.5%) | |
Carneiro | 0.013 | ||
Glandular | 119 (54.5%) | 31 (81.6%) | |
Isolated cells | 62 (28.4%) | 3 (7.9%) | |
Solid | 5 (2.3%) | 2 (5.3%) | |
Mixed | 28 (12.8%) | 2 (5.3%) | |
Non classified | 4 (1.8%) | ||
Ming | 0.021 | ||
Expansive | 56 (26%) | 18 (47.4%) | |
Infiltrative | 153 (71.2%) | 20 (52.6%) | |
Mixed | 6 (2.8%) | — | |
Venous invasion | NS | ||
Positive | 147 (68%) | 24 (63.2%) | |
Negative | 69 (32%) | 14 (36.8%) | |
Nodal metastases a | NS | ||
N0 | 73 (34%) | 9 (23.7%) | |
N+ | 142 (66%) | 29 (76.3%) | |
Clinical stage a | NS | ||
0–IA | 26 (12.1%) | 2 (5.3%) | |
IB | 21 (9.8%) | 3 (7.9%) | |
II | 41 (19%) | 7 (18.4%) | |
IIIA | 50 (23.3%) | 10 (26.3%) | |
IIIB | 35 (16.3%) | 7 (18.4%) | |
IV | 42 (19.5%) | 9 (23.7%) | |
Type of surgery a | NS | ||
Curative | 141 (72.3%) | 23 (67.6%) | |
Palliative | 54 (27.7%) | 11 (32.4%) | |
