Figure 3
From: RASSF1A hypermethylation in pretreatment serum DNA of neuroblastoma patients: a prognostic marker
RASSF1A methylation status of tumour and serum DNA in neuroblastoma patients. M, methylated; U, unmethylated. The sizes of the PCR products for methylated and unmethylated primers are 93 and 105 bp, respectively. (A) Cases stage 1 and 2 with good prognosis tumour DNAs are methylated but absent in the serum DNAs. (B) In contrast, in stage 3 and 4 MYCN-amplified cases, methylated DNAs are detected in both tumour and serum samples.
