Table 4 Various rates of TRM in ALL and AML in both HICs and LICs

Reference	Protocol	HIC vs LIC	Country	TRM (%)
ALL
Christensen et al (2005)	NOPHO ALL92	HIC	Nordic	3.0
Slats et al (2005)	DCOG ALL-6, 7 and 8	HIC	The Netherlands	2.1
Rubnitz et al (2004)	Total Therapy XI-XIV	HIC	United States	2.9
Li et al (2003)	HKALL 93	HIC	Hong Kong	2.8
Wheeler et al (1996)	MRCUKALLX	HIC	United Kingdom	5.6
Gupta S et al (current)	St. Jude's Modified	LIC	El Salvador	12.5
Howard et al (2004)	Total XI, Total XIII	LIC	Brazil	14.9
Metzger et al (2003)	St. Jude's Modified	LIC	Honduras	20.8
Laosombat et al (2002)	Modified CCSG	LIC	Thailand	11.5
Advani et al (1999)	MCP841	LIC	India	16.0
Aziz et al (1997)	Modified BFM	LIC	Pakistan	14.3
AML
Creutzig et al (2006)	AML-BFM 98	HIC	Various	7.2
Ravindranath et al (2005)	POG 8821	HIC	Various	14.4
Slats et al (2005)	DCOG AML-82, 87 and 92/94	HIC	Netherlands	16.6
Creutzig et al (2004)	AML-BFM 93	HIC	Various	9.7
Rubnitz et al (2004)	AML-83, 87, 91, 97	HIC	United States	7.6
Riley et al (1999)	UKMRC AML10	HIC	Various	13.8
Gupta S et al (current)	Modified BFM93	LIC	El Salvador	33.1
Dluzniewska et al (2005)	PPLLSG 98	LIC	Poland	18.0

Abbreviations: ALL=acute lymphoblastic leukaemia; AML=acute myeloid leukaemia; HIC=high-income countries; LIC=low-income country; TRM=treatment-related mortality.

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