Table 2 Effects of the specific nutritional combination (SNC) on cachexia parameters (experiment B)

From: Dietary supplementation with a specific combination of high protein, leucine, and fish oil improves muscle function and daily activity in tumour-bearing cachectic mice

(A) Body, tumour and carcass weight at section (g at day 20)

Treatment

N

BW

Delta BW

TW

CW

Delta CW

CON

10

28.0±0.7*

5.3±0.5*

0.0±0.0*

28.0±0.7*

5.3±0.5*

TB-CON

17

20.8±0.5

−0.7±0.4

2.1±0.1

18.7±0.4

−2.8±0.4

TB-SNC

18

23.1±0.6*

0.9±0.6*

1.7±0.1*

21.4±0.6*

−0.7±0.7*

(B) Organ weights at section (mg at day 20)

Treatment

N

Epididymal fat

mTA

mG

mEDL

mS

CON

10

443±37*

44.5±1.3*

141±4*

9.2±1.1

6.7±0.5*

TB-CON

17

87±18

33.4±0.9

108±2

7.8±0.2

5.3±0.2

TB-SNC

18

189±20*

38.1±0.9*

118±3*

8.3±0.5

5.7±0.2*

(C) Change in BW in time

  

Change in BW (change in g: days 0–20 when compared to day 1)

Treatment

N

0

6

10

15

20

CON

10

1.0±0.3

3.6±0.4

4.3±0.7

5.5±1.0*

6.3±1.4#

TB-CON

17

0.6±0.3

2.7±0.3

3.3±0.3

3.7±0.4

−0.1±0.5

TB-SNC

18

0.9±0.2

3.4±0.3

4.4±0.4

4.6±0.4

1.8±0.6#

(D) Food intake in time

   

Food intake per day (g)

Treatment

N

 

8

13

17

19

CON

10

 

4.4±0.2

4.3±0.2

4.4±0.3

3.5±0.6

TB-CON

17

 

4.0±0.2

4.1±0.1

3.7±0.3

3.5±0.5

TB-SNC

18

 

4.2±0.1

4.5±0.2

4.8±0.3

4.4±0.4

  1. CON=mice receiving control diet B, TB-CON=tumour-bearing mice receiving control diet B, TB-SNC=tumour-bearing mice receiving the specific nutritional combination. BW=body weight; CW=carcass weight; delta BW=BW day 20 minus BW day 0, delta CW=CW day 20 minus CW day 0, TW=tumour weight, mTA=muscle Tibialis Anterior, mG=muscle Gastrocnemius, mEDL=muscle Extensor Digitorum Longus, mS=muscle Soleus.
  2. Data as means±s.e.m.; *significantly different from TB-CON (P<0.05, k=2, α=10%) #significantly different from TB-CON for the whole curve (P<0.05, k=2, α=10%) (For more details about statistics, see the Materials and Methods section).
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