Table 3 Types of K-Ras mutations found in 114 NSCLC tumours
(Codon)mutation a (aminoacid change) | Sequencing (%) b | Hybrisation (%) b | PNA (%) b |
|---|---|---|---|
(12) GGT → AGT (Gly → Ser) | 0 (0) | 0 (0) | 1 (5) |
(12) GGT → CGT (Gly → Arg) | 1 (9) | 1 (6) | 1 (5) |
(12) GGT → TGT (Gly → Cys) | 5 (45.5) | 8 (50) | 10 (48) |
(12) GGT → GAT (Gly → Asp) | 2 (18) | 3 (19) | 5 (24) |
(12) GGT → GCT (Gly → Ala) | 1 (9) | 1 (6) | 1 (5) |
(12) GGT → GTT (Gly → Val) | 2 (18) | 2 (12.5) | 2 (9.5) |
(13) GGC → TGC (Gly → Cys) | 0 (0) | 1 (6) | 1 (5) |
K-Ras mutation | 11 | 16 | 21 |
Wild-type | 103 | 98 | 93 |
Total | 114 | 114 | 114 |
