Table 4 Targets selected for validation

From: MicroRNA deregulation and pathway alterations in nasopharyngeal carcinoma

Target gene

Expression level a

Coregulating miRNAs

Symbol

Normal

NPC

P -value

Down-miR

Ctrl-miR

CCND2

10.87

14.06

<0.0001

miR-200a, 204, 29c, and 497

—

CCNE2

6.53

8.81

<0.0001

miR-195, 200a, 200b, 34c, 449, and 9

—

CDC25A

6.87

9.13

<0.0001

miR-100, 195, 34b, and 497

miR-103 and 27

AKT3

10.55

11.86

0.0232

miR-135a, 139, 195, 29c, 497, and 532

miR-140, 365, and 654

PLCG1

9.88

10.78

0.0135

miR-135a, 200b, 204, and 449

miR-140

VEGFA

11.87

13.57

0.0018

miR-195, 200b, 29c, and 497

miR-186

  1. aExpression levels expressed as 39 – Ct values after normalisation with β-2-microglobulin, actin, and GAPDH.
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