Table 1 The summary of the patient characteristics, preoperative median serum levels of CA125, and expression levels of mesothelin in 87 chemosensitive and 52 resistant ovarian epithelial cancer patients
From: High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
Total population | Chemosensitive | Chemoresistant | P -value | |
|---|---|---|---|---|
Patient number | 139 | 87 | 52 | |
Age (mean±s.d.) | 54.7±11.9 | 52.7±11.2 | 57.9±12.3 | 0.015a |
Gravida | 3.2±2.5 | 2.7±2.5 | 3.7±2.4 | 0.34a |
Parity | 2.2±1.8 | 1.9±1.6 | 2.5±1.8 | 0.43a |
Tumour size (cm) | 10.9±5.8 | 11.9±6.1 | 9.3±5.1 | 0.008a |
Ascites (ml) | ||||
Median (25th to 75th percentile) | 500 (50–2500) | 300 (50–1800) | 1050 (100–3600) | 0.013b |
Menopause | ||||
Yes | 83 (60%) | 50 | 33 | 0.49c |
No | 56 (40%) | 37 | 19 | |
Histology | ||||
Serous | 86 (62%) | 51 | 35 | 0.31c |
Non-serous | 53 (38%) | 36 | 17 | |
Stage | ||||
Early (I and II) | 35 (25%) | 30 | 5 | 0.001c |
Advanced (III and IV) | 104 (75%) | 57 | 47 | |
Grading | ||||
1 and 2 | 35 (25%) | 30 | 5 | 0.069c |
3 | 104 (75%) | 57 | 47 | |
Debulking surgery | ||||
Optimal | 78 (56%) | 60 | 18 | <0.001c |
Suboptimal | 61 (44%) | 27 | 34 | |
Lymph node metastasis | ||||
Yes | 30 (39%) | 17 | 13 | 0.25c |
No | 46 (61%) | 32 | 14 | |
CA125 (U ml−1) | 1046 | 899 | 1320 | |
Median (25th to 75th percentile) | (265–2560) | (253–2344) | (456–4770) | 0.059b |
