Table 2 Serum HE4 and CA125 concentrations in patients with endometriosis, endometrial, and ovarian cancer

From: Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts

  

HE4 (pM)

CA125 (U ml−1)

Diagnosis

n

Mean

s.d.

Median

(range)

P -value a

Mean

s.d.

Median

(range)

P -value a

Controls

66

40.5

10.3

38.6

(27.0–80.7)

—

8.9

6.2

6.7

(2.2–31.2)

—

Endometriosis all

129

45.5

13.4

43.5

(15.2–111.0)

—

35.8

36.0

25.3

(0.8–182.0)

—

 Stage 1

16

46.7

11.4

42.9

(35.1–80.9)

0.96192

15.6

9.8

11.5

(5.1–44.4)

0.34560

 Stage 2

17

44.9

13.1

43.9

(28.7–72.0)

0.99718

21.4

18.4

14.8

(3.5–70.5)

0.09637

 Stage 3

33

43.2

11.4

43.4

(15.2–68.0)

—

25.1

22.7

14.8

(0.9–79.0)

—

 Stage 3 w/o OvEndo

9

43.9

10.1

43.8

(32.6–61.9)

0.99971

23.3

25.4

13.4

(2.6–79.0)

0.58802

 Stage 4

63

46.5

15.0

44.0

(26.8–111.0)

—

50.4

43.1

36.7

(0.8–182.0)

—

 Stage 4 w/o OvEndo

18

43.5

12.1

40.9

(27.4–64.5)

0.99973

40.8

30.9

32.1

(0.8–127.0)

0.00001

 Ovarian endometriosis

69

46.0

14.9

44.0

(15.2–111.0)

0.89441

44.3

42.1

33.7

(0.9–182.0)

0.00000

Endometrial cancer

16

99.2

76.4

73.3

(26.5–330.5)

0.00001

22.0

23.0

15.5

(9.6–106.0)

0.02915

Ovarian cancer

14

1125.4

2670.0

268.3

(46.5–10250.0)

0.00000

1117.1

1971.0

240.0

(6.6–6890.0)

0.00000

      

0.00000b

    

0.00000b

 Serous

7

2031.1

3669.1

562.5

(46.5–10250.0)

—

1938.7

2588.7

341.0

(28.9–6890.0)

—

 Mucinous

3

202.6

189.7

113.0

(74.4–420.5)

—

201.5

186.0

221.0

(6.6–377.0)

—

 Clear cell

2

397.6

477.2

397.6

(60.1–735.0)

—

674.5

587.6

674.5

(259.0–1090.0)

—

 Endometrioid

1

70.0

—

70.0

—

—

97.0

—

97.0

—

—

 Small cell

1

64.1

—

64.1

—

—

17.8

—

17.8

—

—

  1. a Tukey's multiple comparisons of means, in comparison to the healthy controls.
  2. b Comparison to patients with ovarian endometriosis.
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