Figure 5

Comparison of percentage of methylated reference (PMR) values in breast cancer tissue between unmethylated (negative) and methylated (positive) serum samples for (A) adenomatous polyposis coli (APC), (B) ras association domain family protein 1A (RASSF1A) and (C) oestrogen receptor 1 (ESR1). Differences in PMR values between unmethylated and methylated serum samples were examined with the Mann–Whitney U-test. For none of the genes did these differences reach statistical significance.