Table 1 Frequency of methylated genes (% positives) according to clinicopathological features

From: The presence of circulating total DNA and methylated genes is associated with circulating tumour cells in blood from breast cancer patients

Variables

Number of patients

APC

RASSF1A

ESR1

At least one gene methylated

ER

     

 Positive

53

36

47*

19

62*

 Negative

22

18

14

23

36

PR

     

 Positive

38

32

42

16

58

 Negative

35

31

34

26

54

HR

     

 Positive

52

37

48*

19

63*

 Negative

21

19

14

24

38

HER2

     

 Positive

26

35

31

15

58

 Negative

52

27

38

21

50

Triple negative

 Positive

10

20

20

20

30

 Negative

63

33

41

21

60

p53

     

 Positive

18

39

33

22

55

 Negative

33

33

45

24

70

Disease status

 PD

46

39

52*

26

67*

 SD

26

19

12

15

38

  1. Abbreviations: APC=adenomatous polyposis coli; ESR1=oestrogen receptor 1; HR=hormone receptor; PD=progressive disease; RASSF1A=ras association domain family protein 1A; SD=stable disease.
  2. *P-values ⩽0.05.
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