Table 2 Patient and tumour characteristics and HIF-1α staining

From: Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis

 

HIF-1 α, number of patients (%)

 

Negative

Positive

P -value

Gender

P=0.35

 Male

24 (43)

32 (57)

 

 Female

18 (53)

16 (47)

 

T stage

P=0.48

 T1/2

9 (50)

9 (50)

 

 T3/4

33 (46)

39 (54)

 

N stage

P<0.02*

 N0

32 (56)

25 (44)

 

 N1

6 (29)

15 (71)

 

 N2

4 (33)

8 (67)

 

Differentiation

P=0.58

 Well

3 (75)

1 (25)

 

 Moderate

33 (45)

40 (55)

 

 Poor

6 (46)

7 (54)

 

Dukes’ stage

P=0.05

 Dukes’ A

9 (53)

8 (47)

 

 Dukes’ B

23 (58)

17 (42)

 

 Dukes C1

8 (29)

20 (71)

 

 Dukes’ C2

2 (40)

3 (60)

 

Dukes’ stages combined

P<0.02*

 A/B

32

25

 

 C

10

23

 

TNM stage

P<0.05*

 Stage I

9 (53)

8 (47)

 

 Stage II

23 (58)

17 (42)

 

 Stage III

10 (30)

23 (70)

 

Vascular invasion

P<0.005*

 Absent

35 (56)

28 (44)

 

 Intramural

4 (36)

7 (64)

 

 Extramural

3 (19)

13 (81)

 

Microvessel density^

P=0.32

 <60 vessels

20 (53)

18 (47)

 

 ⩾60 vessels

21 (42)

29 (58)

 
  1. HIF=hypoxia-inducible factor; TNM=tumour node metastasis.
  2. *Statistically significant at 5% level.
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