Table 4 Multivariate analysis of survival for HIF-1α

From: Hypoxia-inducible factor-1α and -2α are expressed in most rectal cancers but only hypoxia-inducible factor-1α is associated with prognosis

 

HR

95% CI

P -value

HIF-1α

 Noa

1

  

 Yes

4.108

1.366-12.352

0.012

Vascular invasion

 Noa

1

  

 Intramural

1.483

0.400-5.495

0.555

 Extramural

2.284

0.917-5.688

0.016

TNM stage

 Ia

1

  

 II

1.724

0.197-15.069

0.622

 III

10.048

1.302-77.553

0.027

  1. CI=confidence interval; HIF=hypoxia-inducible factor; HR=hazard ratio; TNM=tumour node metastasis.
  2. aReference values.
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