Table 3 Estimated cumulative risks for breast, prostate, colon and all cancers for first-degree relatives of patients with founder CHEK2 mutations
Cancer site in relatives | CHEK2 mutation type | Cancer risk to age 50; same site in proband | Cancer risk to age of 50; all sites in proband | Cancer risk to age 75; same site in proband | Cancer risk to age of 75; all sites in proband |
|---|---|---|---|---|---|
Breast | Missense | 0.032 | 0.014 | 0.108 | 0.053 |
Truncating | 0.069 | 0.035 | 0.091 | 0.076 | |
Either | 0.042 | 0.019 | 0.104 | 0.059 | |
Colon | Missense | 0.015 | 0.005 | 0.075 | 0.035 |
Truncating | 0.000 | 0.000 | 0.046 | 0.020 | |
Either | 0.012 | 0.003 | 0.070 | 0.031 | |
Prostate | Missense | 0.013 | 0.002 | 0.120 | 0.072 |
Truncating | 0.000 | 0.000 | 0.119 | 0.061 | |
Either | 0.002 | 0.002 | 0.121 | 0.070 | |
Any | Missense | — | 0.039 | — | 0.216 |
Truncating | — | 0.045 | — | 0.248 | |
Either | — | 0.041 | — | 0.223 |
