Table 1 TYMS combined genotypes classified according to expected expression of thymidylate synthase
Expression level | TYMS 5′UTR | TYMS 3′UTR | n | |
|---|---|---|---|---|
G>C SNP (Kawakami and Watanabe, 2003) | High | 2R/3RG,3RC/3RG, 3RG/3RG | — | 58 |
Low | 2R/2R, 2R/3RC, 3RC/3RC | — | 72 | |
Combination A (Hitre et al, 2005) | High | 3R3R | Any genotype | 61 |
2R3R | ins/ins | |||
Low | 2R3R | ins/del–del/del | 69 | |
2R2R | any genotype | |||
High | 2R/3RG,3RC/3RG, 3RG/3RG | ins/ins | 8 | |
Combination B | Intermediate | 2R/3RG,3RC/3RG, 3RG/3RG | ins/del–del/del | 88 |
2R/2R, 2R/3RC, 3RC/3RC | ins/ins | |||
Low | 2R/2R, 2R/3RC, 3RC/3RC | ins/del–del/del | 34 |
