Table 3 Univariate logistic regression of toxicity in 130 patients adjuvantly treated with 5FU chemotherapy

From: Predictors of survival and toxicity in patients on adjuvant therapy with 5-fluorouracil for colorectal cancer

  

TOXICITY

 

n

Events

P

OR

95% CI

Sex

 Female

46

17

0.68

1

—

 Male

84

28

 

0.85

0.40–1.81

Age (years)

 <65

64

17

0.06

1

—

 ⩾65

66

28

 

2.04

0.97–4.26

TYMS VNTR

 2R2R

25

10

0.38

1

—

 2R3R

60

23

 

0.93

0.36–2.42

 3R3R

45

12

 

0.55

0.19–1.54

TYMS G>C

 Low activity

72

25

0.98

1

—

 High activity

58

20

 

0.99

0.48–2.047

TYMS 3′UTR

 ins/ins

46

20

0.10

1

—

 ins/del

68

23

 

0.66

0.31–1.43

 del/del

16

2

 

0.19

0.04–0.91

TYMS comb A

 Low activity

69

25

0.68

1

—

 High activity

61

20

 

0.86

0.41–1.77

TYMS comb B

 Low

34

11

0.09

1

—

 Intermediate

88

28

 

0.98

0.42–2.28

 High

8

6

 

6.27

1.09–36.22

MTHFR C677T

 C/C

44

11

0.08

1

—

 C/T

63

28

 

2.40

1.03÷5.58

 T/T

23

6

 

1.06

0.33–3.36

MTHFR A1298C

 A/A

54

22

0.12

1

—

 A/C

59

21

 

0.80

0.38–1.72

 C/C

17

2

 

0.19

0.04–0.93

MTHFR combined

 Low

42

16

0.75

1

—

 Intermediate

78

25

 

0.77

0.35–1.68

 High

10

4

 

1.08

0.26–4.44

5FU CL (lmin−1Kg−1)

 ⩾0.017

65

10

<0.0001

1

—

 <0.017

65

35

 

6.42

2.79–14.74

  1. Abbreviations: CI=confidence interval; CL=plasma clearance; MTHFR=methylenetetrahydrofolate reductase; OR=odds ratio; UTR=untranslated region; VNTR=variable number tandem repeats.
Back to article page