Figure 1

Immunohistochemical analysis of hnRNP K expression in PCa. (A, B) Representative images of two PCa samples with different total scores (9 and 14, respectively); higher magnification of the areas enclosed with lines are reported in the insets. Elevated hnRNP K staining was present both in the nucleus and cytoplasm of all tumour cells. The dash lines mark the NT areas. The bars correspond to 100 μm in (A) and (B) and 25 μm in the insets. (C) Comparison of the scores of hnRNP K in NT and PCa tissues. The ordinates represent the mean score±s.e. (reported also in the inset); hnRNP K expression was significantly (P<0.0001) higher in PCa compared with NT tissue both in the cytoplasm and the nucleus. (D) Biochemical (PSA) progression-free survival according to hnRNP K expression. The dotted curve corresponds to patients (n=24) whose tumours had a low total score (<10) and the solid curve those (n=24) with high total scores (⩾10); P=0.085.