Figure 3
Prognostic significance of leading edge gene sets associated with MPRED resistance in T-ALL cell lines. Graphs show relapse-free survival in primary ALL patient cohorts (T lineage and B lineage as indicated) predicted based on expression of genes associated with MPRED resistance in T-ALL cell lines. The gene profiles represent the leading edges of the following GSEA gene sets: (A) CHOLESTEROL BIOSYNTHESIS; (B) STRING GLUL TOP100 ASSOCIATIONS (genes associated with glutamine synthetase); (C and D) V$MYC_Q2 (genes regulated by MYC); (E and F) WEI_DOWN_IN_DEX_RESISTANCE (genes associated with DEX resistance); (G) VOXPHOS (oxidative phosphorylation); (H) PENG_RAPAMYCIN_DOWN (genes downregulated in response to rapamycin). Further details of these gene sets can be found in Supplementary Table S4 and Supplementary Data File 4.
