Table 2 Top 10 gene sets from GSEA database C2 (top) and ICHR Curated (bottom) datasets enriched in the MPRED-resistance signature
GSEA rank | C2 Gene set name (C2 dataset) | Functional description | P -value | FDR a |
|---|---|---|---|---|
1 | VOXPHOS | Oxidative phosphorylation | 0.002 | 0.115 |
2 | BIOSYNTHESIS_OF_STEROIDS | Biosynthesis of steroids | 0.013 | 0.108 |
3 | PENG_RAPAMYCIN_DOWN | Downregulated in response to Rapamycin starvation in haematopoietic cells | 0.003 | 0.093 |
4 | PENG_GLUTAMINE_DOWN | Downregulated in response to glutamine starvation in haematopoietic cells | 0.002 | 0.105 |
5 | BRCA1_OVEREXP_DN | Downregulated in response to BRCA1 induction | 0.001 | 0.098 |
6 | CHOLESTEROL_BIOSYNTHESIS | Cholesterol biosynthesis pathway | 0.038 | 0.090 |
7 | ELECTRON_TRANSPORT_CHAIN | Electron transport chain | 0.009 | 0.086 |
8 | GLYCOLYSIS_AND_GLUCONEOGENESIS | Glycolysis and gluconeogenesis pathway | 0.001 | 0.098 |
9 | SCHUMACHER_MYC_P493_TET_UP | Upregulated by MYC expression in human B cells | 0.015 | 0.099 |
10 | IDX_TSA_UP_CLUSTER5 | Upregulated during fibroblast differentiation induced by insulin, DEX, isobutylxanthine | 0.002 | 0.100 |
GSEA rank | Gene set name (ICHR- Curated dataset) | Functional description | P -value | FDR a |
1 | YOCUM_PROTEINS_IN_MLL_CELL_LINES_VS_CD34 | Proteins expressed in MLL-translocated cell lines | 0.001 | 0.030 |
2 | BHOJWANI_EARLY_VS_LATE_PREB_LINREG | Genes differentially expressed between ALL early/late relapse | 0.004 | 0.077 |
3 | YEOH_DAV_MLL | Genes associated with MLL-patient subtypes | 0.007 | 0.684 |
4 | RHODES_NEOPLASTIC_META | Genes associated with the neoplastic phenotype | 0.022 | 0.740 |
5 | STAUNTON_696860 | Response to compound NSC696860 in NCI cell lines | 0.031 | 0.601 |
6 | LAMB_DEX_UP | Upregulated in DEX-sensitive ALL cells | 0.040 | 0.664 |
7 | WEI_DOWN_IN_DEX_RESISTANCE | Downregulated in DEX-resistant ALL cells | 0.040 | 0.569 |
8 | LAMB_COMBINED_PHENOTHIAZINE | Upregulated in response to phenothiazine in cell lines | 0.008 | 0.557 |
9 | KIRSCHNER_SCWABE_ALL_EARLY_VS_LATE_RELAPSE | Genes differentially expressed between early/late ALL relapse | 0.029 | 0.623 |
10 | STAUNTON_668281 | Response to compound NSC668281 in NCI cell lines | 0.034 | 0.577 |
