Table 3 CMAP drugs significantly associated with MPRED- and DEX-resistance gene signatures in T-ALL cell lines
MPRED | DEX | ||||||
|---|---|---|---|---|---|---|---|
Drug | Mechanism of action | Enrichment | P -value | Drug | Mechanism of action | Enrichment | P -value |
LY-294002 | AKT/PI3K inhibitor | −0.507 | 0.0001 | Rapamycin | mTOR inhibitor | −0.653 | <0.0001 |
Trichostatin A | HDAC inhibitor | −0.423 | 0.018 | Geldenamycin | HSP90 inhibitor | 0.655 | 0.004 |
Carbamazepine | Antiepileptic | −0.792 | 0.020 | LY-294002 | AKT/PI3K inhibitor | −0.397 | 0.005 |
W-13 | Calmodulin antagonist | 0.903 | 0.021 | Sodium phenylbutyrate | HDAC inhibitor | −0.564 | 0.014 |
Blebbistatin | Myosin II inhibitor | −0.896 | 0.023 | Quercetin | ROS scavenger/antioxidant | 0.903 | 0.019 |
Wortmannin | AKT/PI3K inhibitor | −0.497 | 0.024 | Resveratrol | ROS scavenger/antioxidant | −0.630 | 0.020 |
Benserazide | Amino-acid decarboxylase inhibitor | 0.885 | 0.028 | Cobalt chloride | Hypoxia mimetic | −0.742 | 0.037 |
Rapamycin | mTOR inhibitor | −0.441 | 0.031 | Fludrocortisone | Steroid | 0.857 | 0.042 |
Indomethacin | Cyclo-oxygenase inhibitor | 0.662 | 0.031 | Deferoxamine | Hypoxia mimetic | −0.717 | 0.049 |
Quercetin | ROS scavenger/antioxidant | 0.876 | 0.033 | Â | Â | Â | Â |
Y-27632 | Rho-kinase inhibitor | −0.872 | 0.036 |  |  |  |  |
Tamoxifen | Oestrogen-receptor blocker | 0.740 | 0.039 | Â | Â | Â | Â |
Resveratrol | ROS scavenger/antioxidant | −0.583 | 0.040 |  |  |  |  |
