Table 3 Multiple regression-derived partial regression coefficients ba (and 95% confidence intervals, CIs) of birth weight (upper panel) and birth length (lower panel) on one standard deviation increments of cord blood levels of IGF-1, IGF-2, and IGFBP-3 in Boston, USA and Shanghai, China, overall and by maternal height. Statistically significant P values (<0.05) are indicated in bold fonts.

From: Insulin-like growth factor levels in cord blood, birth weight and breast cancer risk

 

All women

Women ⩽1.63 m height

Women >1.63 m height

 

Boston ( n =92)

Shanghai ( n =110)

Boston ( n =46)

Shanghai ( n =81)

Boston ( n =46)

Shanghai ( n =29)

 

b (CI)

P -value

b (CI)

P -value

b (CI)

P -value

b (CI)

P -value

b (CI)

P -value

b (CI)

P -value

Birth weight

 IGF-1 (per 44.4 ng ml−1)

141.7 (11.3, 272.1)

0.03

−3.7 (−133.5, 126.0)

0.96

−39.6 (−252.3, 173.1)

0.71

−1.2 (−139.9, 137.4)

0.99

260.4 (92.6, 428.1)

0.003

−33.6 (−420.6, 353.3)

0.86

 IGF−2 (per 132.1 ng ml−1)

7.0 (−131.4, 145.3)

0.92

57.3 (−51.3, 166.0)

0.30

45.5 (−137.2, 228.1)

0.62

−2.3 (−124.1, 119.5)

0.97

1.0 (−196.7, 198.7)

0.99

292.8 (0.59, 584.9)

0.05

Birth length

 IGF-1 (per 44.4 ng ml−1)

0.85 (0.19, 1.51)

0.01

0.00 (−0.91, 0.91)

0.99

0.29 (−0.70, 1.28)

0.56

−0.21 (−1.39, 0.98)

0.73

1.14 (0.09, 2.19)

0.03

0.81 (−0.19, 1.81)

0.11

 IGF-2 (per 132.1 ng ml−1)

0.10 (−0.60, 0.80)

0.77

0.65 (−0.11, 1.41)

0.09

0.44 (−0.41, 1.29)

0.30

0.73 (−0.31, 1.77)

0.17

−0.17 (−1.41, 1.06)

0.78

0.78 (0.02, 1.53)

0.04

  1. IGF=insulin-like growth factor; CI=confidence interval.
  2. a Adjusted for maternal age, height and weight gain, parity, duration of gestation, and gender of offspring in models for all women; adjusted for maternal age and weight gain, and duration of gestation in models by maternal height. In all models, IGF-1 and IGF-2 were adjusted both mutually and for IGFBP-3.
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