Table 2 Logistic regression models of the effect of energy-adjusted intake of total isoflavones on colorectal adenoma

From: Dietary isoflavone and the risk of colorectal adenoma: a case–control study in Japan

 

Quartiles of energy-adjusted intake of total isoflavones (mg per day)

 
 

Lowest

Second

Third

Highest

 
 

(<24.77)

(24.77 to <39.73)

(39.73 to <62.41)

(⩾62.41)

P -value for trend

Men and women

 Controls

174

175

174

174

 

 Cases

226

172

168

155

 

OR (95% CI)a

1.00 (Reference)

0.75 (0.56–1.00)

0.73 (0.54–0.98)

0.67 (0.50–0.90)

<0.01

OR (95% CI)b

1.00 (Reference)

0.77 (0.57–1.04)

0.76 (0.56–1.02)

0.70 (0.51–0.96)

0.03

Men

 Controls

141

120

105

94

 

 Cases

173

119

114

86

 

OR (95% CI)c

1.00 (Reference)

0.78 (0.55–1.10)

0.84 (0.59–1.20)

0.70 (0.49–1.02)

0.09

OR (95% CI)d

1.00 (Reference)

0.80 (0.56–1.14)

0.89 (0.62–1.28)

0.74 (0.50–1.09)

0.18

Women

 Controls

33

55

69

80

 

 Cases

53

53

54

69

 

OR (95% CI)e

1.00 (Reference)

0.59 (0.33–1.05)

0.44 (0.25–0.75)

0.56 (0.33–0.96)

0.03

OR (95% CI)f

1.00 (Reference)

0.53 (0.28–0.98)

0.44 (0.24–0.80)

0.49 (0.27–0.90)

0.03

  1. aAdjusted for age (40–49, 50–54, 55–59, 60–64, ⩾65 years), sex and screening period (first or second).
  2. bAdjusted for age (40–49, 50–54, 55–59, 60–64, ⩾65 years), sex, screening period (first or second), family history of colorectal cancer (yes or no), cigarette smoking (never, ever ⩽20, ever 21–40, ever >40 pack-years), alcohol consumption (never, ever <150, ever 150–299, ever ⩾300 g per week ethanol), body mass index (<21, 21–22, 23–24, ⩾25 kg m−2), physical activity (<31.50, 31.50 to <34.55, ⩾34.55 MET h per day based on controls), supplement use (yes or no) and non-steroidal anti-inflammatory drug use (yes or no).
  3. cAdjusted for age (50–54, 55–59, 60–64, ⩾65 years) and screening period (first or second).
  4. dAdjusted for age (50–54, 55–59, 60–64, ⩾65 years), screening period (first or second), family history of colorectal cancer (yes or no), cigarette smoking (never, ever ⩽20, ever 21–40, ever >40 pack-years), alcohol consumption (never, ever <150, ever 150–299, ever ⩾300 g per week ethanol), body mass index (<21, 21–22, 23–24, ⩾25 kg m−2), physical activity (<31.50, 31.50 to <34.55, ⩾34.55 MET h per day based on controls), supplement use (yes or no) and non-steroidal anti-inflammatory drug use (yes or no).
  5. eAdjusted for age (40–49, 50–54, 55–59, 60–64, ⩾65 years) and screening period (first or second).
  6. fAdjusted for age (40–49, 50–54, 55–59, 60–64, ⩾65 years), screening period (first or second), family history of colorectal cancer (yes or no), cigarette smoking (never, ever ⩽20, ever 21–40, ever >40 pack-years), alcohol consumption (never, ever <150, ever 150–299, ever ⩾300 g per week ethanol), body mass index (<21, 21–22, 23–24, ⩾25 kg m−2), physical activity (<31.50, 31.50 to <34.55, ⩾34.55 MET h per day based on controls), supplement use (yes or no), non-steroidal anti-inflammatory drug use (yes or no), age at menarche (<12, 12–13, ⩾14 years), menopausal status (pre or post) and current use of female hormones (user or non-user).
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