Table 3 Logistic regression models of the effect of energy-adjusted intake of total isoflavones on site, size and number of colorectal adenoma in men and women

From: Dietary isoflavone and the risk of colorectal adenoma: a case–control study in Japan

 

Quartiles of energy-adjusted intake of total isoflavones (mg per day)

 
 

Lowest

Second

Third

Highest

 
 

(<24.77)

(24.77 to <39.73)

(39.73 to <62.41)

(⩾62.41)

P -value for trend

Controls

174

175

174

174

 

Site of adenoma

 Proximal colon

114

90

94

83

 

OR (95% CI)a

1.00 (Reference)

0.75 (0.52–1.08)

0.77 (0.54–1.11)

0.69 (0.47–1.00)

0.07

 Distal colon

82

67

59

52

 

OR (95% CI)a

1.00 (Reference)

0.87 (0.58–1.30)

0.77 (0.51–1.17)

0.71 (0.46–1.09)

0.10

 Rectum

30

15

15

20

 

OR (95% CI)a

1.00 (Reference)

0.47 (0.24–0.93)

0.47 (0.24–0.93)

0.68 (0.36–1.31)

0.18

Size of adenoma

 <5 mm

125

93

97

87

 

OR (95% CI)a

1.00 (Reference)

0.77 (0.54–1.09)

0.79 (0.55–1.12)

0.70 (0.48–1.00)

0.07

 ⩾5 mm

101

79

70

69

 

OR (95% CI)a

1.00 (Reference)

0.74 (0.51–1.08)

0.67 (0.45–0.98)

0.73 (0.49–1.08)

0.08

Number of adenomas

 1 Adenoma

132

85

101

94

 

OR (95% CI)a

1.00 (Reference)

0.64 (0.45–0.91)

0.73 (0.52–1.03)

0.67 (0.47–0.95)

0.05

 >1 Adenomas

94

87

67

61

 

OR (95% CI)a

1.00 (Reference)

0.96 (0.65–1.41)

0.72 (0.48–1.08)

0.74 (0.49–1.12)

0.07

  1. aAdjusted for age (40–49, 50–54, 55–59, 60–64, ⩾65 years), sex, screening period (first or second), family history of colorectal cancer (yes or no), cigarette smoking (never, ever ⩽20, ever 21–40, ever >40 pack-years), alcohol consumption (never, ever <150, ever 150–299, ever ⩾300 g per week ethanol), body mass index (<21, 21–22, 23–24, ⩾25 kg/m2), physical activity (<31.50, 31.50 to <34.55, ⩾34.55 MET h per day based on controls), supplement use (yes or no) and non-steroidal anti-inflammatory drug use (yes or no).
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