Figure 3 | British Journal of Cancer

Figure 3

From: Elevated level of inhibin-α subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer

Figure 3

Effect of INHα over-expression on primary prostate tumour growth and lymph node metastasis. (A–D) Left, immunohistochemistry of primary prostate and lymph node tumours using human mitochondria and INHα staining confirmed the human origin of the cells in LNCaP- and PC3-inoculated mice and INHα expression in the tumours. Bar=200 and 500 μm. (A and B) Primary prostate tumour weights (middle) and primary prostate tumour take (right). (C and D) Incidence of lymph node metastasis (middle) and lymph node volume (right). *P<0.05, **P<0.01, ***P<0.001 and no significant (NS) difference between the mean of the EV clones and the mean to the INHα-transfected clones. The bars represent EV-transfected LNCaP and PC3 clones in grey, INHα-transfected LNCaP and PC3 clones in black. Data are shown as mean±s.e. of the mean.

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