Table 1 Relationships between the expression of INHα and clinicopathological parameters in prostate adenocarcinoma (n=37)

From: Elevated level of inhibin-α subunit is pro-tumourigenic and pro-metastatic and associated with extracapsular spread in advanced prostate cancer

  

Benign regions

Cancer regions (G3/G4)

Stromal regions

Parameters

No. of specimens

Mean intensity

Relative risk (95% CI)

P -value

Mean intensity

Relative risk (95% CI)

P -value

Mean intensity

Relative risk (95% CI)

P -value

Combined Gleason grade

 6

16

0.7

NA

 

1.88

NA

 

0.30

NA

 

 7

14

1.51

NA

 

2.21

NA

 

1.21

NA

 

 ⩾8

7

1.29

NA

 

1.99

NA

 

2.00

NA

 

Extracapsular spread

 Positive

24

1.43

  

2.13

  

1.41

  

 Negative

13

0.65 (reference)

2.07 (1.04–4.13)

0.01a

1.87 (reference)

1.27 (0.76–2.11)

NSa

0.08 (reference)

2.55 (1.39–4.65)

0.0011a

Surgical margins

 Positive

16

1.15

  

1.84

  

1.47

  

 Negative

21

1.12 (reference)

1.15 (0.68–3.08)

NSa

2.18 (reference)

0.71 (0.32–1.53)

NSa

0.50 (reference)

4.75 (1.62–13.93)

0.0006a

VEGFR-3+ vessels

 Positive

18

1.29

  

2.07

  

1.53

  

 Negative

19

0.97 (reference)

1.27 (0.62–2.60)

NSa

2.00 (reference)

1.20 (0.0–2.39)

NSa

0.33 (reference)

2.85 (1.28–6.37)

0.0067a

Lymph node metastasis

 Positive

16

1.41

  

2.06

  

1.93

  

 Negative

21

1.01 (reference)

1.62 (0.67–3.97)

NSa

2.00 (reference)

0.84 (0.48–1.46)

NSa

0.15 (reference)

13.22 (1.94–90.00)

<0.0001a

  1. Abbreviations: VEGFR=vascular endothelial growth factor receptor; NA=not applicable; NS=not significant; CI=confidence interval.
  2. aFisher's exact test.
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