Table 4 Overall survival univariate analyses (parametric and 1000-permutation tests)

From: Validation of UBE2C protein as a prognostic marker in node-positive breast cancer

Variable

HR

HR 95% CI

Parametric P -value

1000-permutation P -value

Age

1.06

1.01–1.12

0.026

0.022

Histology

    

 IDC vs others

0.48

0.18–1.27

0.139

0.149

Histological size

    

 Raw value

1.02

0.99–1.05

0.133

0.157

 <20 mm vs ⩾20 mm

2.97

0.68–12.94

0.147

0.090

SBR

    

 I vs II vs III

3.97

1.67–9.47

0.001

<0.001

SBR

    

 I, II vs III

5.93

2.08–16.89

0.001

<0.001

 No positive nodes

1.28

1.15–1.42

<0.001

<0.001

Positive nodes

    

 1 vs 2 vs 3 vs > 3

1.81

1.19–2.74

0.005

0.002

Positive nodes

    

 <3 vs ⩾3

3.89

1.53–9.89

0.004

0.002

ER

    

 + vs −

0.18

0.07–0.47

<0.001

<0.001

PR

    

 + vs −

0.51

0.19–1.37

0.182

0.210

Hormonotherapy

    

 + vs −

0.34

0.13–0.92

0.034

0.037

IHC Ki-67 raw value

1.03

1.01–1.05

0.001

0.005

IHC Ki-67

    

 <11% vs ⩾11%

8.59

1.14–64.57

0.037

0.003

IHC UBE2C raw value

    
 

1.03

1.01–1.05

<0.001

0.002

IHC UBE2C

    

 <11% vs ⩾11%

7.14

1.64–31.11

0.009

<0.001

NPI raw value

2.70

1.66–4.41

<0.001

<0.001

NPI scores

    

 1 vs 2 vs 3

4.48

1.74–11.52

0.002

<0.001

NPI

    

 1, 2 vs 3

4.74

1.77–12.69

0.002

<0.001

  1. CI=confidence interval; ER=oestrogen receptor; HR=hazard ratio; IDC=infiltrating ductal carcinoma; IHC=immunohistochemistry; NPI=Nottingham prognostic index; PR=progesterone receptor; SBR=Scarff–Bloom–Richardson.
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