Figure 2
From: Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia
Framework of mathematical model for myelomonocytic haematopoiesis. HSCs that have long-term repopulating ability are mostly in the G0 phase and these cells are denoted as quiescent HSCs. Quiescent HSCs recruited into the cell cycle (cycling HSC) replenish themselves or differentiate into MPPs, CMPs, and GMPs in sequence. Equivalent cells in the assays are shown on the right side. N denotes the number of cells, r the transfer/mitotic rate, and P the branching probability.
