Figure 4

Simulation of temporal changes in CFU-G/M and CAFC frequencies. The lines indicate the simulation results. The markers represent mean values of the experimental data shown in Figure 3 (circle, CFU-G/M; triangle, day-14 CAFC; and cross, day-28 CAFC). ‘Variable’ parameters were continuously modulated with time in the simulation. The time course of the parameter changes can be divided into three prominent phases and are shown above the graph (see main text for details).