Figure 7
From: Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia
Probability of the AML-specific mutational events in a 3 Gy-exposed mouse during 300 days post irradiation. The probability was calculated from the cumulative number of cell divisions in each cell compartment based on poisson statistics. A constant rate for the AML-specific Sfpi1 mutation, 1 × 10−9 per cell division, was assumed for all cell types.
