Table 1 Parameter values used in the simulation

From: Implication of replicative stress-related stem cell ageing in radiation-induced murine leukaemia

Parameter

Steady state a

Recovery phase b

References c

r 1

0.03 [/d]

Variable

Bradford et al (1997); Sudo et al (2000)

r 2

0.8 [/d]

Variable

Passegué et al (2005)

r 3

0.55 [/d]

Variable

Passegué et al (2005)

r 4

1.9 [/d]

Passegué et al (2005)

r 5

2.5 [/d]

Passegué et al (2005)

P 21

0.5−P22

Variable

 

P 22

0.462

Variable

 

P 23

1−P21−P22

 

P 33

0.480

 

P 34

0.5 (1−P33)

 

P 44

0.457

Variable

 

P 45

0.75 (1−P44)

Spangrude and Johnson (1990)

P 55

0.320

 
  1. aValues for the unexposed steady state.
  2. bValues for 3 Gy-exposed mice. Parameters modulated in response to haematopoietic demands are denoted as ‘variable’.
  3. cReferences for the values or the relational expressions. For details, see the Supplementary material.
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