Figure 4

Angiogenesis in 4T1.2 mammary fat pad tumours. Sections were stained with anti-MECA32 to identify blood vessels. Negative control shown in (A). Representative sections stained for MECA32 from the mammary fat pad tumours transfected with (B) empty vector (pCMV), (C) plasmid expressing wild-type IGFBP4 (pCMV-BP4) or (D) plasmid expressing protease-resistant IGFBP4 (pCMV-dBP4). (Original magnification, Ă— 400).