Table 1 Percentage Annexin V-positive (early apoptotic) ECV304 and H292 cells 72 h after treatment with gemcitabine for 24 h and/or radiotherapy

From: The role of apoptotic cell death in the radiosensitising effect of gemcitabine

dFdC immediately before RT

0 Gy

2 Gy

6 Gy

ECV304

 0 nM

9.17±2.38

10.86±1.74

18.76±5.87*

 2 nM

10.20±1.36

11.18±2.33

17.19±2.30

 8 nM

14.28±1.68*

18.34±8.41§

31.83±7.31§,

H292

 0 nM

4.00±1.55

6.52±2.39

13.53±4.04*

 4 nM

4.77±0.72

5.55±1.51

15.61±1.20††

 18 nM

20.06±5.09*

26.94±5.34**

38.26±7.82,§§

dFdC immediately after RT

ECV304

 0 nM

12.67±2.93

12.56±4.50

23.16±2.70

 2 nM

5.73±3.40

13.06±4.57

19.18±7.33

 8 nM

7.35±5.35

7.30±4.13

17.18±7.07

H292

 0 nM

4.02±1.94

5.68±4.37

9.49±4.66

 4 nM

3.42±1.91

2.20±0.75

5.60±3.12

 18 nM

5.26±1.24

7.24±5.55

11.42±1.33§§

  1. *P<0.05 vs 0 nM+0 Gy, P<0.05 vs 2 nM+0 Gy, §P<0.05 vs 8 nM+0 Gy, P<0.05 vs 0 nM+6 Gy, **P<0.05 vs 0 nM+2 Gy, ††P<0.05 vs 4 nM+0 Gy, §§P<0.05 vs 18 nM+0 Gy.