Table 1 Haematological and non-haematological adverse events occurring in ⩾20% of patients or reaching grade 4 severity
Adverse event | Any grade, n =15 (%) | Grade 1 n (%) | Grade 2 n (%) | Grade 3 n (%) | Grade 4 n (%) |
|---|---|---|---|---|---|
Haematological adverse events | |||||
Neutropenia | 13 (86) | — | 2 (13) | 3 (20) | 8 (53) |
Anemia | 11 (73) | 3 (20) | 6 (40) | 2 (13) | — |
Leukopenia | 11 (73) | — | 3 (20) | 5 (33) | 3 (20) |
Lymphopenia | 5 (33) | 1 (7) | 1 (7) | 2 (13) | 1 (7) |
Thrombocytopenia | 2 (13) | — | 1 (7) | 1 (7) | — |
Neutropenic fever | 2 (13) | — | — | 2 (13) | — |
Non-haematological adverse events | |||||
Nausea | 12 (80) | 10 (67) | 2 (13) | — | — |
Asthenia | 10 (67) | 6 (40) | 3 (20) | 1 (7) | — |
Pain | 8 (53) | 3 (20) | 3 (20) | 1 (7) | 1 (7) |
Vomiting | 8 (53) | 4 (27) | 3 (20) | 1 (7) | — |
Chills | 7 (47) | 3 (20) | 4 (27) | — | — |
Cough | 5 (33) | 4 (27) | — | 1 (7) | — |
Fever | 5 (33) | 4 (27) | 1 (7) | — | — |
Anorexia | 5 (33) | 3 (20) | 1 (7) | 1 (7) | |
Alopecia | 5 (33) | 4 (27) | 1 (7) | — | — |
Constipation | 4 (27) | 1 (7) | 3 (20) | — | — |
Mucositis | 4 (27) | 2 (13) | 2 (13) | — | — |
Insomnia | 4 (27) | 3 (20) | 1 (7) | — | — |
GGTP increase | 3 (20) | 1 (7) | 1 (7) | 1 (7) | |
Gastritis | 3 (20) | 1 (7) | 2 (13) | — | — |
Headache | 3 (20) | 1 (7) | 2 (13) | — | — |
Dysphagia | 3 (20) | 3 (20) | — | — | — |
AMI | 1 (7) | — | — | — | 1 (7) |
Pulmonary embolism | 1 (7) | — | — | — | 1 (7) |
