Table 1 Tyrosine kinase substrates on the kinase array that were differentially phosphorylated between primary UM cell lines and metastatic cell lines
From: Episodic Src activation in uveal melanoma revealed by kinase activity profiling
Substrate | UniProt ID | Position | Log fold change | Adj. P -value | Kinase |
|---|---|---|---|---|---|
CDK2 | P24941 | T14/Y15 | 5.3 | 0.00005 | Lyn |
FRK | P42685 | Y387 | 6.2 | 0.0002 | Unknown |
SRC8 | Q14247 | Y499 | 4.6 | 0.006 | Src |
ENOG | P09104 | Y43 | 4.7 | 0.01 | Src |
EFS | O43281 | Y253 | 3.1 | 0.01 | Src |
PLCG1 | P19174 | Y771 | 4.2 | 0.01 | Syk, Sky, GFRs |
CD79A | P11912 | Y182/Y188 | 3.1 | 0.01 | Lyn |
PAXI | P49023 | Y118 | 4.0 | 0.02 | FAK, Src, Brk |
PAXI | P49023 | Y31 | 4.3 | 0.03 | FAK, Src, Brk |
